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Sunday, May 5, 2013
Saturday, May 4, 2013
Blackhawks edge Wild 5-2 in Game 2
CHICAGO (AP) ? No playoff jitters for the Chicago Blackhawks this time. Just a strong start and impressive finish.
Patrick Sharp and Michael Frolik had two goals apiece, and the Blackhawks beat the Minnesota Wild 5-2 on Friday night in Game 2 of their first-round playoff series.
Patrick Kane added two assists as Chicago peppered Minnesota goalie Josh Harding after an uneven performance in Game 1 on Tuesday night. Bryan Bickell added an empty-net score to his overtime goal in the Blackhawks' 2-1 victory in the playoff opener.
Game 3 is Sunday afternoon in Minnesota.
Devin Setoguchi and Marco Scandella scored for the Wild, who are making their first postseason appearance in five years. Harding, once again subbing for Niklas Backstrom, made 43 saves.
Setoguchi gave the Wild a spark when he teamed with Matt Cullen for a beautiful 2-on-1 rush at end of the second period. Cullen passed across the ice to Setoguchi, who beat Corey Crawford into the upper right corner to trim Chicago's lead to 2-1.
But the Blackhawks turned up the pressure in the third period, and Sharp stuffed one in from the right side of the net to restore the two-goal advantage. Kane then made a slick pass to set up Sharp for his 25th career playoff goal, putting the game away with six minutes left.
It was one sweet night for Sharp, who missed much of the season with a shoulder injury. He had only six goals and 14 assists in 28 games while the Blackhawks rolled to the Presidents' Trophy for most points in the league this season.
Minnesota squeaked into the playoffs with a victory over Colorado in its final game. But the Blackhawks got off to a slow start in Game 1 and the Wild came close to stealing home-ice advantage.
No such problems this time for Chicago.
While chalking up their slow first period in the playoff opener to nerves, the Blackhawks focused on a better beginning to Game 2 and delivered an impressive start.
Chicago pressured Harding early and finished with 17 shots in the first period, compared to seven for Minnesota. And even with all that pressure, the Blackhawks needed a couple of fortunate caroms to build a 2-0 lead.
Andrew Shaw's slap shot deflected off Justin Falk and went underneath fellow Wild defenseman Tom Gilbert to Frolik, who flipped it into the upper left corner to put Chicago in front with 11:26 left in the first period. Frolik was in the right place at the right time again in the second, sending Duncan Keith's deflected pass through Harding's legs just 49 seconds into the period.
It was the first short-handed goal allowed by the Wild all season and lifted Frolik to six goals in 13 career playoff games.
Shaw also had two assists and Crawford finished with 26 saves in his seventh playoff win for Chicago, which is 19-2 in playoff series when winning the first two games.
The Wild played without goalie Niklas Backstrom and forward Jason Pominville for the second straight game, and defenseman Clayton Stoner also was sidelined by an injury. Backstrom was scratched from Game 1 when he hurt himself during warm-ups, and his return could be key to Minnesota's hopes of turning around the series.
NOTES: The Wild have not won a playoff game since a 3-2 victory at Colorado on April 14, 2008. The Wild lost the last three games of that quarterfinal series, and then went five years without a postseason appearance before they lost to the Blackhawks on Tuesday night. ... Frolik's short-handed goal was the first for the Blackhawks in the playoffs since Game 7 of the 2011 Western Conference quarterfinals against Vancouver.
___
Jay Cohen can be reached at http://www.twitter.com/jcohenap
Source: http://news.yahoo.com/blackhawks-edge-wild-5-2-game-2-041431721.html
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Scientists create genetically altered mice to model human disease
Friday, May 3, 2013
Whitehead Institute Founding Member Rudolf Jaenisch, who helped transform the study of genetics by creating the first transgenic mouse in 1974, is again revolutionizing how genetically altered animal models are created and perhaps even redefining what species may serve as models.
"This new method is a game changer," says Jaenisch, who is also a professor of biology at MIT. "We can now make a mouse with five mutations in just three to four weeks, whereas the conventional way would take three to four years. And it's rather straightforward, probably even easier than the conventional way."
Scientists create models in mice by altering specific genes that have been associated with a given disease. The models allow for the study of the development and course of the disease and the effects of various interventions, including genetic and chemical. For the past 20 years, the creation of such models has remained relatively unchanged: scientists insert a piece of DNA into a mouse embryonic stem (ES) cell, inject the modified cell into a very early-stage embryo, called a blastocyst, then implant this developing ball of cells into a foster female mouse. The whole process can take years and tens of thousands of dollars to establish a mouse strain with, for example, a single copy of a gene "knocked out". Such knockouts can only be created in very few species, including mice and rats, whose ES cells can be grown and modified reliably.
The new approach used by scientists in Jaenisch's lab bypasses ES cells to quickly and efficiently produce mice with mutations in both copies of multiple genes. In next week's issue of the journal Cell, Haoyi Wang, Hui Yang, and Chikdu Shivalila describe their technique, which is based on a system that certain bacteria use to fend off viral attacks.
This is the first time that the system, known as CRISPR (for "clustered regularly interspaced short palindromic repeat")/Cas (for "CRISPR-associated"), has been used to alter multiple genes in a single multicellular organism. Shivalila says the process is so accessible that he expects other labs to adopt it quickly.
"For any institution or university with a core facility, we think this will be the way they will start making mice carrying specific mutations because it's a lot faster and so efficient," says Shivalila, one of Jaenisch's graduate students. "We were surprised that we could get two genes 'knocked out' at four loci very, very efficiently, about 80% efficiency. If we used TALENs, a more recent and complicated development in genetic engineering, we got 30% efficiency for just one gene."
Because the CRISPR/Cas technique can generate mutant mice even without using ES cells, a limitation of the conventional method for making models, genetic research may no longer be confined to a limited list of model organisms?those for which ES cells exist.
"This breaks down the definition of model organism," says Wang, a postdoctoral researcher in Jaenisch's lab. "So now, even with limited resources, any animal with established embryo manipulation procedures could be the subject of genome engineering. With many of the animals' genomes that have been sequenced, we could use this technology to establish efficient genetic manipulations in more species, to study the unique biology of each, and to learn more about evolution."
Thus, Wang, Yang, and Shivalila have used CRISPR/Cas to create mouse models only, but the team is excited broaden its application to other animals.
"We also need to see if the CRISPR/Cas system has any unexpected, undesired off-target effects, changes to the genome that we don't want," says Yang, a postdoctoral researcher in the Jaenisch lab. "So we need study this further to establish the fidelity of the system. But I think this will be the way to go."
###
"One-step generation of mice carrying mutations in multiple genes by CRISPR-Cas mediated genome engineering"
Cell, May 9, 2013
Whitehead Institute for Biomedical Research: http://www.wi.mit.edu/index.html
Thanks to Whitehead Institute for Biomedical Research for this article.
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Source: http://www.labspaces.net/128114/Scientists_create_genetically_altered_mice_to_model_human_disease
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Friday, May 3, 2013
How to clean seaweed from beaches: Dry it and use the biomass for energy
May 3, 2013 ? A research group at the University of Alicante (Spain) has invented an algae removal and treatment system that turns this underused residue into a renewable source of energy: biomass. The process involves several stages of washing, drying and compacting without leaving the beach. Therefore, according to the team led by Professor Irene Sentana Gadea, the system is cheaper, more efficient and more environmentally friendly than the procedure commonly followed now.
With the invention, protected with a national patent, up to an 80 percent of the weight and volume currently removed would stay on the beaches, as now with the seaweed water and sand are also sent to rubbish tips or treatment plants. Professor Eloy Sentana Cremades says that as well as considerable savings on transportation, the new procedure would allow to give more uses to the dried seaweed.
The system is based on a moving platform with wheels where three hoppers are installed. The first receives shovelfuls of wet seaweed with sand attached. Seawater is pumped in and poured back into the sea dragging the sand with it. In the next hopper, water purified with a solar-powered device would wash most of the residual salt from the algae, and in the third hopper it would be dried with air heated also by solar energy. The clean and dry seaweed could be then pressed by a system similar to the one used by rubbish trucks or converted into bales or pellets, ready to be commercialized. No chemical products would be used in the process.
The method currently used has drawbacks such as the deterioration of beaches due to the extraction of sand that then has to be replaced, the weight of the waste, and the saturation of certain landfills to which it is taken. Also, as the material is impregnated with sand and salt and mixed with other wastes, the use of the dead seaweed is limited to rudimentary applications, such as aerating the ground for agricultural purposes.
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Wedding Hair: The Big Day Is A Woman's Biggest 'Hair Moment,' Joico Survey Finds
Your Big Day is a big day for your hair, too.
In a survey conducted by Wakefield Research on behalf of national hair brand Joico, 73 percent of American women agreed that the biggest ?hair moment? of a woman?s life is her wedding. In fact, one out of three women said they?d rather trip while walking down the aisle than have a wedding day hair "fail."
However, most brides said they didn't plan their hairstyle more than eight days before the wedding.
No matter how long your hair is, there are tons of cute options for your wedding day. Click through the slideshow below for some wedding hair inspiration. And don't forget about Mom -- check out Joico's advice on hairstyles for both the bride and the her mother here.
Keep in touch! Check out HuffPost Weddings on Facebook, Twitter and Pinterest.
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Beyond Kepler: New Missions to Search for Alien Planets
NASA's groundbreaking planet-hunting Kepler observatory may be showing its age, but a handful of other spacecraft are poised to join the search for exoplanets and carry it into the future.
The Kepler spacecraft has detected more than 2,700 potential alien planets since its March 2009 launch, revolutionizing scientists' understanding of worlds beyond our solar system. But the second of the telescope's four reaction wheels ? devices that maintain the observatory's position in space ? may be about to fail, putting the prolific mission's future in doubt.
While no instrument is likely to replace Kepler or its capabilities anytime soon, reinforcements are on their way to the launchpad. The first is scheduled to blast off this October, in fact ? the European Space Agency's Gaia mission. [Gallery: A World of Kepler Planets]
Gaia is designed to create an extremely accurate 3D map of about 1 billion Milky Way stars ? 1 percent of our galaxy's total. This work could detect tens of thousands of new planetary systems, scientists say.
"Researchers hope that Gaia will tell them more about the distribution of exoplanets around the galaxy: Are there more near the center or in the spiral arms? Are planets more common in areas rich in heavy elements?" reporters Yudhijit Bhattacharjee and Daniel Clery write in a special exoplanet section in the journal Science released online today (May 2).
Europe aims to loft another exoplanet mission in 2017. ESA's Characterizing Exoplanets Satellite, or CHEOPS, will stare at nearby stars known to host planets, watching for these worlds to cross their stars' faces. (Kepler uses this technique, known as the transit method, to detect alien worlds.)
"High precision measurements by the satellite should help astronomers nail down planet sizes," Bhattacharjee and Clery write. Data gathered from the ground should provide these worlds' masses, allowing astronomers to figure out their density, the reporters add.
NASA plans to launch a planet-hunter of its own in 2017, the Transiting Exoplanet Survey Satellite. TESS will use the transit method to search for worlds orbiting nearby stars, with a focus on Earth-size planets that may be capable of supporting life.
Astronomers hope to then point NASA's powerful James Webb Space Telescope? an $8.8 billion instrument slated for launch in late 2018 ? at the most promising of these newfound worlds, scanning their atmospheres for water vapor and gases that may have been produced by living organisms, such as oxygen, nitrous oxide and methane.
Additions to the planet-hunting picture get a bit murky beyond 2017. But many researchers are hopeful that NASA will be able to build and launch a roughly $1.5 billion observatory called the Wide-Field Infrared Survey Telescope.
In 2010, the U.S. National Research Council deemed WFIRST the top priority for the next decade of astronomical research. The telescope would not only hunt for exoplanets but also probe the mysteries of dark energy and galaxy evolution, among other phenomena.
If approved and funded, WFIRST could potentially launch in a decade or so. But the proposed mission remains in a sort of limbo at the moment.
All this talk about exoplanet space missions is not to discount, of course, the many finds that have been made from the ground.
A number of research groups around the world have employed Earth-based instruments ? the HARPS spectrograph, on a telescope in Chile, and the HIRES spectrograph, on Hawaii's Keck Telescope, are two examples ? to spot exoplanets. These scientists often use the radial velocity method, which picks up tiny gravitational wobbles that orbiting worlds induce in their parent stars.
But Kepler's success has spurred some of these researchers to change tacks temporarily, according to Bhattacharjee and Clery.
"Since the Kepler space mission began detecting new candidate exoplanets by the thousands using the transit technique, radial velocity teams have changed focus from discovering new planets to confirming Kepler detections and measuring their mass," they write.
Follow Mike Wall on Twitter?@michaeldwall?and?Google+.?Follow us @Spacedotcom, Facebook or Google+. Originally published on SPACE.com.
Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/beyond-kepler-missions-search-alien-planets-192011704.html
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Around the world, angry workers unite on May Day
A Cambodian garment factory worker, left, is her face painted with the U.S. currency sign as she joins a rally on May Day in Phnom Penh, Cambodia, Wednesday, May 1, 2013. They demand the government an increase in wages and better working condition. (AP Photo/Heng Sinith)
A Cambodian garment factory worker, left, is her face painted with the U.S. currency sign as she joins a rally on May Day in Phnom Penh, Cambodia, Wednesday, May 1, 2013. They demand the government an increase in wages and better working condition. (AP Photo/Heng Sinith)
A Cambodian Buddhist monk, center, together with local workers march on May Day in Phnom Penh, Cambodia, Wednesday, May 1, 2013. They demand the government an increase in wages and better working condition. (AP Photo/Heng Sinith)
Cambodian garment factory workers stage a rally to mark the May Day in Phnom Penh, Cambodia, Wednesday, May 1, 2013. The rally participants called the government for a raise in their minimum wages and better working condition. (AP Photo/Heng Sinith)
Cambodian garment factory workers hold papers written with their demands during a rally to mark the May Day in Phnom Penh, Cambodia, Wednesday, May 1, 2013. The rally participants called the government for a raise in their minimum wages and better working condition. (AP Photo/Heng Sinith)
Indonesian workers with their faces and bodies painted in white and an Indonesian word "Buruh" that means "Workers" in red take part in a rally commemorating May Day in Jakarta, Indonesia, Wednesday, May 1, 2013. (AP Photo/Achmad Ibrahim)
ISTANBUL (AP) ? Workers around the world united in anger during May Day rallies Wednesday ? from fury in Europe over years of austerity measures that have cut wages, reduced benefits and eliminated many jobs altogether, to rage in Asia over relentlessly low pay, the rising cost of living and hideous working conditions that have left hundreds dead in recent months alone.
In protests, parades, strikes and other demonstrations held in cities across the planet, activists lashed out at political and business leaders they allege have ignored workers' voices or enriched themselves at the expense of laborers during what has been a difficult few years for the global economy. In some places, the demonstrations turned violent, with activists clashing with police.
The pain was especially fresh in Bangladesh, where the collapse last week of an illegally built eight-story facility housing multiple garment factories killed more than 400 in a Dhaka suburb. The building collapse followed a garment factory fire in November that killed 112 people in the country, and it has increased the pressure on the global garment industry to improve working conditions.
A loud procession of thousands of workers wound through central Dhaka on Wednesday. Many waved the national flag and demanded the death penalty for the now-detained owner of the doomed building. From a loudspeaker on the back of a truck, a participant spoke for the throngs gathered: "My brother has died. My sister has died. Their blood will not be valueless."
The Bangladesh tragedy drew a denunciation from Pope Francis as he addressed worshippers at a private Mass at the Vatican. He blasted what he called the "slave" wages of those who died, many of whom were being buried Wednesday as other bodies were still being pulled from the rubble. Francis criticized the focus on "balance books" and personal profit that he said are tied to the failure to pay workers fair wages.
In Greece and Spain, increasing numbers of people are losing their jobs as governments grappling with a debt crisis have been cutting spending, raising taxes and pursuing other stinging austerity measures. Both countries have unemployment rates hovering just above 27 percent.
Unions in Greece held a May Day strike that brought ferry and train services to a halt, and organized peaceful protest marches through central Athens. The country, which nearly went bankrupt in 2010, is now in its sixth year of a deep recession and is dependent on international bailout loans.
While the austerity drive has succeeded in reducing high budget deficits, it has been at a huge cost: under the terms of its latest loan disbursement, Athens has agreed to sack about 15,000 civil servants through 2014.
"We are here to send a message to ... those in power in Europe, that we will continue our struggle against unfair, open-ended policies that are destroying millions of jobs on a national and European level," said Kostas Tsikrikas, leader of Greek public sector labor union ADEDY.
More than 100,000 Spaniards infuriated by austerity measures and economic recession took to the streets of some 80 cities in trade union-organized rallies Wednesday, with the largest protests in Madrid, Barcelona and Bilbao.
Under banners reading "Fight for your rights," union leaders Ignacio Fernandez Toxo of Workers Commissions and Candido Mendez of the General Workers Union called on the government to reverse its austerity drive and urged politicians to agree an all-party economic plan aimed at creating jobs.
Francisco Moreno, an unemployed bookkeeper, scoffed at Spanish leaders' calls on the public to be patient. "You can only be patient if you have savings, money in the bank," the 47-year-old said. "You can't be patient if you have no income and kids to feed."
May Day events in Turkey turned violent when some demonstrators, angered at a government ban on a symbolic rally point, hurled stones, gasoline bombs and fireworks at riot police. Security forces used water cannon and tear gas to prevent crowds from accessing Taksim Square, and Istanbul Governor Huseyin Avni Mutlu said 22 police officers and at least three passersby were injured. More than 72 demonstrators were arrested.
The square is the city's main hub and is undergoing a major facelift. Authorities banned celebrations at Taksim this year, citing construction safety risks, and partially suspended public transport services to prevent large gatherings there. But trade unions had vowed to mark May Day in Taksim, which has symbolic importance because dozens of protesters were killed there in 1977 when unidentified gunmen opened fire on May Day celebrators.
"Taksim is our sacred venue. Open it up to the workers!" demanded Kani Beko, leader of a major labor union confederation.
Danish Prime Minister Helle Thorning-Schmidt became a target of both booing and a water pistol during a May Day parade in her country, where some believe that she has been leaning too far to the right to uphold the goals of her leftist Social Democratic Party.
Boos and whistles from protesters forced Thorning-Schmidt to abort her speech to thousands at the gathering in Aarhus, some 200 kilometers (125 miles) northwest of Copenhagen. Then, as she was walking to her car, a man squirted water on her with a water pistol. Police spokesman Carsten Dahl said police had detained the 23-year-old man, but the premier was not injured.
Swedish police said seven people were arrested and five were injured as counter-demonstrators tried to interrupt a May Day parade by right-wing extremists in the southern city of Jonkoping. Police spokesman Goran Gunnarsson said 60 others were briefly detained as officers tried to keep the two sides apart.
In Indonesia, the world's fourth-most populous country, tens of thousands of workers rallied for higher pay and other demands. Some also carried banners reading: "Sentence corruptors to death and seize their properties" to protest a proposal for the government to slash fuel subsidies that have kept the country's pump prices among the cheapest in the region.
In the Philippines, an estimated 8,000 workers marched in Manila to also demand better pay and regular jobs instead of contractual work. Some rallied outside the U.S. Embassy, torching a wooden painting stamped with the words "low wages" and "union busting" that depicted Philippine President Benigno Aquino III as a lackey of President Barack Obama.
More than 10,000 Taiwanese protested a government plan to cut pension payouts to solve worsening fiscal problems, saying it reflects a longstanding government policy to bolster economic growth at the expense of workers' benefits. Analysts say poor income levels have forced many young Taiwanese to share housing with their parents and delay marriages.
And in Cambodia, more than 5,000 garment workers marched in Phnom Penh, demanding better working conditions and a salary increase from $80 to $150 a month. About a half million people work in the country's $4.6 billion garment industry, which makes brand name clothes for many U.S. and European retailers.
____
Associated Press writers Margie Mason and Ali Kotarumalos in Jakarta, Indonesia; Teresa Cerojano in Manila, Philippines; Annie Huang in Taipei, Taiwan; Sopheng Cheang in Phnom Penh, Cambodia; Heather Tan in Singapore; Kelvin Chan in Hong Kong; and Chris Blake and Farid Hossain in Savar, Bangladesh, Nicholas Paphitis in Athens, Karl Ritter in Stockholm, and Harold Heckle in Madrid contributed to this report.
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